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Pharmacokinetics and effects of 9-Amino-1,2,3,4-tetrahydroacridine in the immediate postoperative period in neurosurgical patients

✍ Scribed by Hartvig, Per; Pettersson, Elisabeth; Wiklund, Lars; Lindström, Björn

Book ID: 123137602
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 654 KB
Volume: 3
Category: Article
ISSN: 0952-8180
DOI: 10.1016/0952-8180(91)90011-B

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We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the