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Pharmacokinetics and clinical efficacy of oral morphine solution and controlled-release morphine tablets in cancer patients

โœ Scribed by Michael P. Thirlwell; Paul A. Sloan; Jean A. Maroun; Gerry J. Boos; Jean-Guy Besner; John H. Stewart; Balfour M. Mount

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
835 KB
Volume
63
Category
Article
ISSN
0008-543X

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Immediate-release oral morphine, given every four hours in individually titrated doses, is effective in the control of severe cancer pain. To evaluate the analgesic efficacy of a controlled-release morphine sulfate preparation, MS Contin tablets (MSC, Purdue Frederick, Toronto, Ontario, Canada), aft

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## Background: Controlled-release (cr) morphine tablets have become routine therapy in the management of cancer pain. compared with immediate-release (ir) morphine, this formulation provides the benefit of dosing every 12 hours. ## Methods: This study reviewed the 10 published, well controlled, r