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Pharmacokinetics and biotransformation of hydralazine acetone hydrazone, a metabolite of hydralazine, in the rat

✍ Scribed by Masahiro Iwaki; Taro Ogiso; Yoshimasa Ito


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
698 KB
Volume
78
Category
Article
ISSN
0022-3549

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## Abstract The main objective of this study was to determine the pharmacokinetics of the enantiomers of desbutylhalofantrine (DHF), a metabolite of halofantrine (HF), in the rat. Rats received either intravenous (2 mg/kg) or oral (7 mg/kg) (Β±)‐DHF HCl, or (Β±)‐HF HCl intravenously (3 mg/kg). Enanti