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Pharmacokinetics and bioavailability of diacetolol, the main metabolite of acebutolol

โœ Scribed by B. Flouvat; A. Roux; N. P. Chau; M. Viallet; X. Andre-Fouet; R. Woehrle; J. Gregoire


Book ID
104811767
Publisher
Springer
Year
1981
Tongue
English
Weight
455 KB
Volume
19
Category
Article
ISSN
0031-6970

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A stereoselective direct liquid chromatographic method for assay of the enantiomers of the โค-adrenergic blocker acebutolol (AC) and its active metabolite, diacetolol (DC), in human serum was developed. The assay is based on extraction with ethyl acetate and separation of enantiomers on an amylose tr