Pharmacokinetics and antitumor effects of mitoxantrone after intratumoral or intraarterial hepatic administration in rabbits
โ Scribed by Luis H. Ramirez; Zhongxin Zhao; Philippe Rougier; Caroline Bognel; Radan Dzodic; Gilles Vassal; Patrice Ardouin; Alain Gouyette; J.-N. Munck
- Book ID
- 105994011
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 263 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0344-5704
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Deacetyl diltiazem (M 1 ) is a major metabolite of the widely used calcium antagonist diltiazem (DTZ). In order to study the pharmacokinetic and haemodynamic effects of this metabolite, M 1 was administered as a single 5 mg kg -1 dose intravenously (iv) to New Zealand white rabbits (n = 5) via a mar
Pharmacokinetics and therapeutic effects of oltipraz were evaluated after consecutive (once per day at 30 mg/kg/day for 7 and 14 days) or intermittent (once per week at 100 mg/kg/week for 1-3 weeks) oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. The AUC of oltipraz