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Pharmacokinetic/pharmacodynamic modelling and in vitro simulation of dynamic voriconazole–Candida interactions

✍ Scribed by Yanjun Li; M. Hong Nguyen; Stephan Schmidt; Li Zhong; Hartmut Derendorf; Cornelius J. Clancy


Book ID
119260158
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
912 KB
Volume
34
Category
Article
ISSN
0924-8579

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A pharmacokinetic (PK)/pharmacodynamic (PD) modeling strategy to explain the data from an in vitro dynamic model is proposed. Two carbapenem antibiotics, doripenem and meropenem, and three Pseudomonas aeruginosa strains were used as example drugs and strains. The PD model we originally developed to