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Pharmacokinetic–pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients

✍ Scribed by Scott A. Van Wart; David R. Andes; Paul G. Ambrose; Sujata M. Bhavnani

Book ID
116408627
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
374 KB
Volume
63
Category
Article
ISSN
0732-8893

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Pharmacokinetic/pharmacodynamic modeling
Pharmacokinetic/pharmacodynamic modeling and simulation to determine effective dosage regimens for doripenem
✍ Katsube, Takayuki (author);Yano, Yoshitaka (author);Wajima, Toshihiro (author);Y 📂 Article 📅 2010 🏛 John Wiley and Sons Inc. 🌐 English ⚖ 170 KB

The aim of this study was to obtain information on effective dosage regimens of doripenem by a modeling and simulation approach based on pharmacokinetic (PK)/pharmacodynamic (PD) theory. The PK/PD model we have already developed was modified to explain in vitro bactericidal kinetics of doripenem for