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Pharmacokinetic–pharmacodynamic modeling of the miotic effects of dihydrocodeine in humans

✍ Scribed by Helmut Schmidt; Jörn Lötsch


Publisher
Springer
Year
2007
Tongue
English
Weight
413 KB
Volume
63
Category
Article
ISSN
0031-6970

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The prediction of chemotherapeutic efficacy is complicated by "protocol dependencies" in dose-effect and dose-toxicity relationships. It has been proposed that pharmacokinetic-pharmacodynamic mathematical models may allow characterization of chemotherapeutic protocol dependencies, and may facilitate