Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

In vivo pharmacokinetic screening in cas

In vivo pharmacokinetic screening in cassette dosing experiments: the use of on-line prospekt® liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery

✍ Francis Beaudry; J. C. Yves Le Blanc; Michel Coutu; Nigel K. Brown 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 2 views

Drug discovery is a fast growing field and the number of compounds generated daily by the pharmaceutical industry is enormous. The necessity of developing new experimental strategies and analytical methods to rapidly screen the pharmacokinetics (PK) behavior of these compounds becomes a real challen