✦ LIBER ✦

Pharmacokinetic profiles of glycyrrhizin in patients with chronic hepatitis

✍ Scribed by Naomi Tanaka; Yoshikazu Yamamura; Tomofumi Santa; Hajime Kotaki; Katsuyoshi Uchino; Yasufumi Sawada; Tatsuya Aikawa; Toshiaki Osuga; Tatsuji Iga

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 319 KB
Volume: 14
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510140707

No coin nor oath required. For personal study only.

✦ Synopsis

The pharmacokinetics of glycyrrh~n (G) in eight patients with chronic hepatitis receiving chronically i.v. administration of 120 mg dose of G was investigated. The plasma concentration of G in the patients after dosing declined in a monophasic manner.

However, the pharmacokinetic profiles varied among patients. The mean elimination half-life ( t l A ) and the total body clearance (CL,,,) were 6.0 h (range 4.3-10.7 h) and 7.9ml h-I kg-I (4-5-12-7 ml h-I kg-I), respectively. The variation of the CL,,, for G was closely related to that of aspartate aminotransferase (r= -0.739, peO.05) and alanine aminotransferase (r= -0,783, p<O*O5) activities in the plasma.

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