Pharmacokinetics and metabolism of encai
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Patrice Jaillon
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Article
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1990
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Springer US
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English
β 404 KB
The metabolism of encainide occurs in the liver and is polymorphically distributed according to the same genetic factor that determines the 4-hydroxylation of debrisoquine. Over 90% of patients are extensive metabolizers (EM) in whom the oral bioavailability of encainide is only 30% because of exten