Pharmacokinetic profile and placental transfer of a single intravenous injection of [14C]chlorpyrifos in pregnant rats
โ Scribed by Ali A. Abdel-Rahman; Gregory M. Blumenthal; Sherif A. Abou-Donia; Fouad A. Ali; A. Abdel-Monem; Mohamed B. Abou-Donia
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 152 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0340-5761
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## Abstract The toxicokinetics of benzo(a)pyrene (BaP) and 3โhydroxybenzo(a)pyrene (3โOHBaP) were assessed in 36 male SpragueโDawley rats injected intravenously with 40 ยตmolโkg^1^ of BaP to explain the reported atypical urinary excretion profile of 3โOHBaP. Blood, liver, kidney, lung, adipose tissu
All-trans-retinoyl-b-D-glucuronide (RAG) is an endogenous active metabolite of all-trans-retinoic acid (ATRA). In the present study, the pharmacokinetics of RAG was examined after the administration of a single intravenous does (5, 10, or 15 mmol/kg) and of multiple daily intravenous doses (5 mmol/k