Pharmacokinetic-pharmacodynamic modelling of the convulsant interaction between norfloxacin and biphenyl acetic acid in rats
✍ Scribed by Sandrine Marchand; Claudine Pariat; Serge Bouquet; Philippe Courtois; William Couet
- Book ID
- 110004939
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 186 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0007-1188
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of gemifloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of gemifloxacin at a rate of 4 mg kg of body weight
This work proposes a model to characterize the additivity or the nonadditivity of combinations of more than two agents. Using a Bayesian framework, we modeled the variability between experimental subjects, the errors that occurred during data collection, and the relationship between effects and conc