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Pharmacokinetic, pharmacodynamic, and safety profiles of PEGylated interferon beta-1a in healthy volunteers: Results from two Phase 1 clinical studies

✍ Scribed by Gudarz Davar; Sandra Richman; Stacy Hitchman; Gabrielle Glick; Meena Subramanyam; Xiao Hu; Michaela Lerner; Larisa Miller; Ivan Nestorov; Shifang Liu; Ying Zhu; Darren Baker; Michael A. Panzara


Book ID
116398901
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
108 KB
Volume
48
Category
Article
ISSN
1043-4666

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Pharmacokinetic and pharmacodynamic comp
✍ Idrian GarcΓ­a-GarcΓ­a; Carlos A GonzΓ‘lez-Delgado; Carmen M Valenzuela-Silva; Alin πŸ“‚ Article πŸ“… 2010 πŸ› BioMed Central 🌐 English βš– 297 KB

## Background Interferon (IFN) alpha conjugation to polyethylene glycol (PEG) results in a better pharmacokinetic profile and efficacy. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety properties of a new, locally developed, 40-kDa PEG-IFN alpha-2b preparation wi