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Pharmacokinetic-Pharmacodynamic Analysis of the Glucose-Lowering Effect of Metformin in Diabetic Rats Reveals First-Pass Pharmacodynamic Effect

โœ Scribed by Stepensky, D.

Book ID
115511007
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2002
Tongue
English
Weight
404 KB
Volume
30
Category
Article
ISSN
0090-9556

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๐Ÿ“œ SIMILAR VOLUMES

Dose-independent pharmacokinetics of met
Dose-independent pharmacokinetics of metformin in rats: Hepatic and gastrointestinal first-pass effects
โœ Young H. Choi; Sang G. Kim; Myung G. Lee ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 151 KB

Pharmacokinetic parameters of metformin were evaluated after intravenous and oral administration (50, 100, and 200 mg/kg) in rats. The hepatic, gastric, and intestinal first-pass effects were also measured after intravenous, intraportal, intragastric, and intraduodenal administration (100 mg/kg) in