𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[11C]verapamil positron emission tomography

✍ Scribed by Julia Müllauer, Claudia Kuntner, Martin Bauer, Jens P Bankstahl…

Book ID
120730489
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
949 KB
Volume
2
Category
Article
ISSN
2191-219X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Fully automated high yield synthesis of
Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography
✍ Gert Luurtsema; Albert D. Windhorst; Martien P.J. Mooijer; Jacobus D.M. Herschei 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 118 KB 👁 1 views

## Abstract Racemic (±) verapamil is a well characterized substrate for P‐glycoprotein (P‐gp). However, the __in vivo__ pharmacokinetics and pharmacodynamics of both enantiomers are reported to be different. In the preparation of evaluation studies of both enantiomers in animals and humans, the pur