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Pharmacokinetic interactions of tolazamide and oxyphenbutazone in dogs

โœ Scribed by S. E. Abidi; A. H. Kibbe; R. W. Cleary; A. B. Jones; E. C. Harland


Book ID
102915368
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
523 KB
Volume
71
Category
Article
ISSN
0022-3549

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The pharmacokinetic interaction between diltiazem and amiodarone was investigated in dogs. In the presence of amiodarone, diltiazem's AUC values were sigmfkantly increased and its total body clearance and volume of distribution at steady-state significantly decreased. This study indicates that cardi