Stereoselective pharmacokinetics of ibuprofen (IB) enantiomers were studied in rats. Unidirectional conversion from R-ibuprofen (R-IB) to S-ibuprofen (S-IB) was observed following intravenous administration. S-IB concentrations in plasma following racemate administration were simulated according to
Pharmacokinetic implications of stereoselective changes in plasma–protein binding: Warfarin/sulfinpyrazone
✍ Scribed by Stephen Toon; William F. Trager
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 386 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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## Abstract __Purpose__. To characterize the pharmacokinetics of cetirizine enantiomers in the guinea pig including protein binding in both the guinea pig and human plasma. __Methods__. Plasma concentrations of cetirizine enantiomers in the guinea pig were determined using a LC‐MS/MS method after
d e n quantitation of small sulfamethazine peaks impractical. The chloroform wash of the basic aqueous mixture seems to affect this component m a t . Overwashing at this point, however, causes a loss of sulfamethazine. Homogenizing or grinding the tissue prior to extraction tends to improve recover