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Pharmacokinetic evidence for possible renal accumulation of model organic anions in rats

✍ Scribed by Janardan B. Nagwekar; Joo Wha Cheon


Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
521 KB
Volume
70
Category
Article
ISSN
0022-3549

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Sotalol (STL) is an amphoteric, chiral p-adrenergic blocking drug useful in the treatment of both hypertension and ventricular arrhythmias. In the human and rat, STL enantiomers are predominantly cleared from the body by the kidney as intact drug. The renal clearance (a,) of STL enantiomers substant