✦ LIBER ✦
Pharmacokinetic evidence for improved ophthalmic drug delivery by reduction of instilled volume
✍ Scribed by Thomas F. Patton
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 242 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
The bioavailability of topically applied pilocarpine nitrate was studied as a function of instilled volume. As the instilled volume decreased, the fraction of dose absorbed increased. The relationship between fraction absorbed and instilled volume was not direct, but appropriate adjustment of instilled volume and concentration should permit substantial dosage reductions without sacrifice of drug concentration in the eye. The implications of these findings from both a therapeutic and toxicity standpoint are discussed.