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Pharmacokinetic characteristics of two different formulations of trimipramine determined with a new GLC method

✍ Scribed by Gilles Caillé; Jean-Guy Besner; Y. Lacasse; M. Vézina

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
329 KB
Volume
1
Category
Article
ISSN
0142-2782

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✦ Synopsis

Abstract

A sensitive and specific gas chromatographic method using a nitrogen detector for the measurement of trimipramine plasma concentrations is described. This method was used to determine the relative bioavailability and some pharmacokinetic parameters of two formulations, tablets and capsules, in healthy volunteers. It was concluded the tablet and capsule formulations were pharmacokinetically equivalent.

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