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Pharmacokinetic aspects of drug effects in vitro (II) placental transfer to the embryo and activity of some carboxylic acids structurally related to valproic acid in whole embryos in culture

✍ Scribed by Nau, H.; Lewandowski, C.; Klug, S.; Neubert, D.

Book ID: 122396527
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 599 KB
Volume: 2
Category: Article
ISSN: 0887-2333
DOI: 10.1016/0887-2333(88)90004-5

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Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture

✍ Constanze Lewandowski; Stephan Klug; Heinz Nau; Diether Neubert 📂 Article 📅 1986 🏛 Springer-Verlag 🌐 English ⚖ 369 KB

Pharmacokinetic studies were performed in connection with culture experiments. Using the technique of cultivating whole rat embryos of the early postimplantation stage, we measured the concentration of valproic acid (VPA) and 2-en-VPA in the culture medium (free and protein-bound form) and in embryo