Pharmacokinetic principles in the design
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Wing K. Cheung; B. Michael Silber; Avraham Yacobi
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Article
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1991
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John Wiley and Sons
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English
β 567 KB
The potential advantages and disadvantages of incorporating an immediate-release (IR) component in sustained-release formulations with zero-order release characteristics (SR) are discussed. The dose of the IR component for SR doses other than the first one (DIS) should be less than that for the firs