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Pharmacokinetic and Pharmacodynamic Modeling of a Humanized Anti-IL-13 Antibody in Naive and Ascaris-Challenged Cynomolgus Monkeys

โœ Scribed by Yulia Vugmeyster; Xianbin Tian; Pamela Szklut; Marion Kasaian; Xin Xu


Publisher
Springer US
Year
2008
Tongue
English
Weight
360 KB
Volume
26
Category
Article
ISSN
0724-8741

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## Abstract **BACKGROUND:** Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and ILโ€23 and inhibits their pharmacological activity. To evaluate potential effects of ustekinumab treatment during pregnancy, developmental studies were conducted in cynomol