Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration

✍ Scribed by Brigham, Elizabeth; Quinn, Kevin; Kwong, Grace; Willits, Chris; Goldbach, Erich; Motter, Ruth; Lee, Michael; Hu, Kang; Wallace, William; Kholodenko, Dora; Tang-Tanaka, Pearl; Ni, Huifang; Hemphill, Susanna; Chen, Xiao-hua; Eichenbaum, Tovah; Ruslim, Lany; Nguyen, Lan; Santiago, Pamela; Liao, Anna; Bova, Michael; Probst, Gary; Dappen, Michael; Jagodzinski, Jacek; Basi, Guriqbal; Ness, Daniel

• Book ID: 123198144
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 43 KB
• Volume: 6
• Category: Article
• ISSN: 1552-5260
• DOI: 10.1016/j.jalz.2010.05.1821