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Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension

โœ Scribed by Hiroshi Watanabe; Kazuhiro Kosuge; Shinichiro Nishio; Hiroshi Yamada; Shinya Uchida; Hiroshi Satoh; Hideharu Hayashi; Takashi Ishizaki; Kyoichi Ohashi


Book ID
116717619
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
313 KB
Volume
76
Category
Article
ISSN
0024-3205

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Pharmacokinetic interaction between dilt
โœ Joseph Ben David; Meir Bialer ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 312 KB ๐Ÿ‘ 2 views

The pharmacokinetic interaction between diltiazem and amiodarone was investigated in dogs. In the presence of amiodarone, diltiazem's AUC values were sigmfkantly increased and its total body clearance and volume of distribution at steady-state significantly decreased. This study indicates that cardi