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Pharmacokinetic and pharmacodynamic effects of high-dose monoclonal antibody therapy in a rat model of immune thrombocytopenia

✍ Scribed by Feng Jin; Zia R. Tayab; Joseph P. Balthasar

Book ID
111766832
Publisher
American Association of Pharmaceutical Scientists
Year
2005
Tongue
English
Weight
220 KB
Volume
7
Category
Article
ISSN
1550-7416

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Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopenia
✍ Ryan J. Hansen; Joseph P. Balthasar πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 143 KB

Recently, our laboratory reported that intravenous immunoglobulin (IVIG) treatment increased antiplatelet antibody (7E3) clearance in a rat model of immune thrombocytopenic purpura (ITP). However, due to the multifaceted nature of IVIG therapy, the contribution of this increase in antiplatelet antib