Pharmacokinetic and pharmacodynamic comparison of conventional and controlled release formulations of motoprolol in healthy chinese subjects
β Scribed by Yuan-Teh Lee; Chiau-Suang Liau; Ellick C. K. Wong; Wen-Jone Chen; Mingo-Fong Chen; Cueng-Chi Chen
- Publisher
- Springer US
- Year
- 1989
- Tongue
- English
- Weight
- 424 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0920-3206
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The pharmacokinetics and beta-adrenoceptor blocking effects of conventional and sustained-release metipranolol have been studied in 6 healthy male volunteers given a single oral dose of 40 mg. Plasma drug concentrations determined by TLC and a radioreceptor assay, and the inhibition of exercise-indu
We have studied a controlled-release formulation containing metoprolol 100 mg and hydrochlorothiazide 12.5 mg. We compared the pharmacokinetics of both substances and the pharmacodynamics of metoprolol with those of a conventional combination tablet. The controlled-release formulation gave less vari