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Pharmacokinetic and metabolic fate of potassium canrenoate (SC-14266) in man

✍ Scribed by A. Karim; R. E. Ranney; H. I. Maibach

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 775 KB
Volume: 60
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600600510

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✦ Synopsis

The metabolism of intravenously administered radioactive potassium canrenoate (SC-14266-3H) was studied in three men. Within 5 days, 47.45 f 4.17z of the administered radioactivity was recovered in urineand 14.36 f 0.lZX in the feces. In the urine, canrenone was identified as the major metabolite in the free fraction, and the major water-soluble metabolite was identified as the glucuronic acid ester conjugate of the hydroxy acid analog of SC-14266. The elimination of the total radioactivity in the plasma occurred in three phases, their half-lives being 0.073,0.85, and 43.31 hr., respectively. The disappearance of the total label during the first and second phases was predominantly due to the excretion of the hydroxy acid derivative and canrenone. The third phase was a function of the excretion of the conjugate. Three hours after administration of the drug, the plasma levels of the hydroxy acid and canrenone were similar and declined, with a half-life of 8.25 hr.

Keyphrases 0 Canrenoate-$H, potassium (SC-l4266)-pharmacokinetic, metabolic fate, human 0 Pharmacokinetic parameterspotassium canrenoate-3H in human 0 Metabolites, potassium can-~ ~-

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