Pharmacogenomics in Clinical Therapeutics

• Publisher: Wiley-Blackwell
• Year: 2012
• Tongue: English
• Leaves: 249
• Category: Library

✦ Synopsis

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring.

Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions.

From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.Content:
Chapter 1 Pharmacogenomics Principles: Introduction to Personalized Medicine (pages 1–14): Parvaz Madadi and Gideon Koren
Chapter 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? (pages 15–25): Christine L. H. Snozek, Loralie J. Langman and Amitava Dasgupta
Chapter 3 Pharmacogenomics Aspect of Warfarin Therapy (pages 26–38): Matthew D. Krasowski
Chapter 4 Pharmacogenetics and Cancer Chemotherapy (pages 39–52): Christine L. H. Snozek
Chapter 5 Pharmacogenomic Considerations in Anesthesia and Pain Management (pages 53–69): Christine M. Formea and Wayne T. Nicholson
Chapter 6 Pharmacogenomics of Immunosuppressants (pages 70–97): Nicolas Picard and Pierre Marquet
Chapter 7 Pharmacogenomics of Cardiovascular Drugs (pages 98–126): Linnea M. Baudhuin
Chapter 8 Pharmacogenomic Aspects of Antiretroviral Therapy (pages 127–143): Natella Y. Rakhmanina and John N. van den Anker
Chapter 9 Pharmacogenetics of Psychoactive Drugs (pages 144–175): Jorge L. Sepulveda
Chapter 10 Pharmacogenomic Aspects of Adverse Drug–Drug Interactions (pages 176–184): Loralie J. Langman and Christine L. H. Snozek
Chapter 11 Microarray Technology and Other Methods in Pharmacogenomics Testing (pages 185–200): Jorge L. Sepulveda
Chapter 12 Pharmacogenetic Testing in the Clinical Laboratory Environment (pages 201–223): Mark P. Borgman and Mark W. Linder