The term pharmacogenomics is a recent arrival in the literature, but it is a term that anyone interested in pharmacogenetics cannot overlook. The increasing prevalence of the term reflects the progressive transition from genetics to genomics that is taking place in pharmaceutical science. The most famous research in genomics is a worldwide program called the Human Genome Project, a massive effort that is expected to change the science of human biology, including our understanding of human disease. For anyone concerned with drugs and pharmacology, the arrival of the term pharmacogenomics is a reflection of this broad change. Historical aspects of pharmacogenetics / Werner Kalow Pharmacogenomics biomarkers, and the promise of personalized medicine / B. Michael Silber Current status : pharmacogenetics/drug metabolism / Leif Bertilsson Pharmacogentics receptors / Wendell W. Weber Pharmacogentics of drug transporters / Richard B. Kim, Grant R. Wilkenson Interethnic differences in drug response / Werner Kalow Pharmacogentics : clinical viewpoints / Urs. A. Meyer Tools of the trade : the technologies and challenges of pharmocogenetics / Glenn A. Miller Molecular diagnostics and development of biotechnology-based diagnostics / Tracy L. Stockley, Peter N. Ray Technologies for the analysis of single-nucleotide polymorphism : an overview / Denis M. Cerant, Michael S. Phillips Multiplex fluorescent minisequencing applied to the typing of genes encoding drug-metabolizing enzymes / Gisela Sitbon, Ann-Christine SyvaΜnen Multiplex genotyping by specialized mass spectrometry / Phillip L. Ross [and others] Serial analysis of gene expression : transcriptional insights and functional biology / Stephen L. Madden, Clarence Wang, Greg Landes Proteomics / Frank A. Witzmann Bioinformatics : WWW resources / Siu Tang, Daiga Helmeste Applied bioinformatics / David L. Hydman, Masato Mitsuhashi Mapping of disease loci / Glenys Thomson Positional cloning and disease gene identification / Mark S. Silverberg, Andrew P. Boright, Katherine A. Siminovitch General conclusions and future directions / Werner Kalow, Arno G. Motulsky.