𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacogenetics of phenylethylamine: Determination of heritability and genetic transmission of locomotor effects in recombinant inbred strains of mice

✍ Scribed by Dilip V. Jeste; David M. Stoff; Robert Rawlings; Richard Jed Wyatt

Publisher
Springer
Year
1984
Tongue
English
Weight
445 KB
Volume
84
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

beta-Phenylethylamine (PEA) is an amphetamine-like compound that is postulated to be a possible endogenous psychotogen. We studied locomotor response to PEA in two inbred progenitor strains of mice (C57BL/6 By and BALB/c By), their reciprocal F1 hybrids (B6CF1 and CB6F1), and seven recombinant inbred strains (CXBD, CXBE, CXBG, CXBH, CXBI, CXGJ, and CXBK). Univariate and multivariate statistical analyses were done. Heritability of the response to PEA was 82%. The strain distribution pattern was suggestive of the inheritance of the trait through a single major gene locus.

πŸ“œ SIMILAR VOLUMES

Segregation of genetic determinants for
Segregation of genetic determinants for murine glucuroinidase synthesis and loss in CXB recombinant-inbred strains
✍ Gordon Watson; Kenneth Paigen πŸ“‚ Article πŸ“… 1978 πŸ› Springer 🌐 English βš– 366 KB

A set of recombinant-inbred strains developed from mouse strains BALB/c and C57BL/6 includes two beta-glucuronidase phenotypes that are not seen in either of the progenitor strains. These new recombinant phenotypes indicate that glucuronidase levels are regulated by genes additional to the Gur locus

Hepatocarcinogenesis in BXH recombinant
Hepatocarcinogenesis in BXH recombinant inbred strains of mice: Analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci
✍ Gang-Hong Lee; Norman R. Drinkwater πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 813 KB

## Abstract The hepatocarcinogen sensitivity (__Hcs__) loci were originally identified as determinants of the approximately 50‐fold higher susceptibility of male C3H/HeJ (C3H) mice to perinatally induced hepatocarcinogenesis relative to male C57BL/6J (B6) mice. These two inbred strains also differ

The SMXA: a new set of recombinant inbre
The SMXA: a new set of recombinant inbred strain of mice consisting of 26 substrains and their genetic profile
✍ M. Nishimura; N. Hirayama; T. Serikawa; K. Kanehira; Y. Matsushima; H. Katoh; S. πŸ“‚ Article πŸ“… 1995 πŸ› Springer-Verlag 🌐 English βš– 898 KB

A new set of recombinant inbred (RI) strain SMXA consisting of 26 substrains was established between SM/J and A/J. The history of the SMXA RI strains and their genetic profile covering 158 genetic marker loci are reported. From the strain distribution pattern among SMXA RI strains, the chromosomal l