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Pharmacogenetic Testing for Uridine Diphosphate Glucuronosyltransferase 1A1 Polymorphisms: Are We There Yet?

โœ Scribed by Dr. Minoli A. Perera; Dr. Federico Innocenti; Dr. Mark J. Ratain

Book ID
115049744
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
163 KB
Volume
28
Category
Article
ISSN
0277-0008

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Cost effectiveness of pharmacogenetic te
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โœ Heather Taffet Gold; Michael J. Hall; Victoria Blinder; Bruce R. Schackman ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 201 KB

## Abstract ## BACKGROUND: The objective of this study was to examine the cost effectiveness of using a pharmacogenetic test for uridine diphosphate glycosyltransferase 1A1\*28 (UGT1A1\*28) variant homozygosity before administering irinotecan to patients with metastatic colorectal cancer. ## METH

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## Abstract Pharmacogenetic research indicates a relationship between a polymorphism in the gene encoding uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) and irinotecan inactivation, in that degradation of SNโ€38, the active metabolite of irinotecan, correlates inversely with the number of