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Pharmacodynamics of the hydrolysis-activation of the cardioprotective agent (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane

✍ Scribed by Brian B. Hasinoff


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
467 KB
Volume
83
Category
Article
ISSN
0022-3549

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High-performance liquid chromatography (HPLC) and fast atom bombardment mass spectrometry (FAB-MS) were employed to separate and identify the aqueous decomposition products of (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)-propane (ICRF-187; 1), a drug active against several forms of human cancer and which a