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Pharmacodynamics of nicotine: implications for rational treatment of nicotine addiction

โœ Scribed by NEAL L. BENOWITZ


Book ID
108593876
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
349 KB
Volume
86
Category
Article
ISSN
0965-2140

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Like many psychostimulant drugs, nicotine elevates extracellular and synaptic dopamine (DA) concentrations in the nucleus accumbens (NAc). This elevation has been linked to its reinforcing properties. Dopaminergic transmission within the NAc is modulated by gamma-aminobutyric acid (GABA). Therefore,