𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacodynamics and tolerability of L-654,066, a steroid 5α-reductase inhibitor, in men

✍ Scribed by Depré, Marleen; Meeter, Carol; Van Hecken, Anne; Laskin, Oscar L; Buntinx, Agnes; De Schepper, Paul J


Book ID
109845135
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
286 KB
Volume
52
Category
Article
ISSN
0009-9236

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Determination of L-654,066, a new 5α-red
✍ J. D. Gilbert; T. V. Olah; A. Barrish; T. F. Greber 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 480 KB

L-654,066 is a new 5 alpha-reductase inhibitor. A sensitive and specific assay based on combined liquid chromatography/mass spectrometry has been developed for the determination of this drug candidate in plasma. The analyte was isolated from plasma by solid-phase extraction on a C-18 cartridge. A re

FRM146687, a novel steroid 5α-reductase
✍ Nakayama, Osamu; Hirosumi, Jiro; Chida, Noboru; Takahashi, Satoru; Sawada, Kozo; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 524 KB

## BACKGROUND. Steroid 5␣-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the in vitro and in vivo effects of FR146687, a new inhibitor of 5␣-reductase. METHODS. Two isozymes of rat and human 5␣-reductases were expressed in 293 cells. In vivo effects o