Dose-dependent pharmacokinetics of flavo
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Giovanna Damia; Maria Luisa Zanette; Cosmo Rossi; Rosella Mandelli; Aurora Ferra
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Article
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1988
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Springer
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English
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The pharmacokinetics of the novel anticancer agent, flavone acetic acid (FAA) were investigated in Balb-c mice treated with i.v. doses of 100 mg/kg or 300 mg/kg, using an HPLC assay. The kinetics of disappearance from plasma was monoexponential and dose-dependent. After 100 mg/kg, the plasma peak le