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Pharmacodynamics and causes of dose-dependent pharmacokinetics of flavone-8-acetic acid (LM-975; NSC-347512) in mice

โœ Scribed by Guy G. Chabot; Marie-Christine Bissery; Thomas H. Corbett; Kathleen Rutkowski; Laurence H. Baker


Publisher
Springer
Year
1989
Tongue
English
Weight
867 KB
Volume
24
Category
Article
ISSN
0344-5704

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Dose-dependent pharmacokinetics of flavo
โœ Giovanna Damia; Maria Luisa Zanette; Cosmo Rossi; Rosella Mandelli; Aurora Ferra ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 421 KB

The pharmacokinetics of the novel anticancer agent, flavone acetic acid (FAA) were investigated in Balb-c mice treated with i.v. doses of 100 mg/kg or 300 mg/kg, using an HPLC assay. The kinetics of disappearance from plasma was monoexponential and dose-dependent. After 100 mg/kg, the plasma peak le