We have shown that intravenous (i.v.) administration of anti-methotrexate (MTX) antibodies (AMAb) reduces the systemic exposure of intraperitoneal (i.p.) MTX therapy, and we have proposed that AMAb effects on MTX systemic exposure would allow a reduction in MTX-induced systemic toxicity (i.e., produ
β¦ LIBER β¦
Pharmacodynamic modeling of chemotherapeutic effects: Application of a transit compartment model to characterize methotrexate effects in vitro
β Scribed by Lobo, Evelyn D. ;Balthasar, Joseph P.
- Book ID
- 111766929
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 342 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1530-9932
- DOI
- 10.1208/ps040442
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Application of pharmacokineticβpharmacod
β
Evelyn D. Lobo; David M. Soda; Joseph P. Balthasar
π
Article
π
2003
π
John Wiley and Sons
π
English
β 263 KB
Application of effect-compartment model
β
David E. Smith; Henry S. H. Lau; Jeffrey L. Fox
π
Article
π
1983
π
Springer
π
English
β 652 KB
Effects of chemotherapeutic agents 5-flu
β
Foley, John J. (author);Raffa, Robert B. (author);Walker, Ellen A. (author)
π
Article
π
2008
π
Springer
π
English
β 243 KB
Effects of chemotherapeutic agents 5-flu
β
Foley, John J. (author);Raffa, Robert B. (author);Walker, Ellen A. (author)
π
Article
π
2008
π
Springer
π
English
β 243 KB
Application of model-based methods to ch
β
Xingang Li; Liang Li; Xipei Wang; Yupeng Ren; Tianyan Zhou; Wei Lu
π
Article
π
2012
π
John Wiley and Sons
π
English
β 668 KB
Pharmacokinetic-pharmacodynamic modellin
β
Richard N Upton; Guy L Ludbrook
π
Article
π
2005
π
BioMed Central
π
English
β 737 KB
## Background There have been few reports of pharmacokinetic models that have been linked to models of the cardiovascular system. Such models could predict the cardiovascular effects of a drug under a variety of circumstances. Limiting factors may be the lack of a suitably simple cardiovascular mod