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Pharmacodynamic modeling of chemotherapeutic effects: Application of a transit compartment model to characterize methotrexate effects in vitro

✍ Scribed by Lobo, Evelyn D. ;Balthasar, Joseph P.


Book ID
111766929
Publisher
Springer US
Year
2002
Tongue
English
Weight
342 KB
Volume
4
Category
Article
ISSN
1530-9932

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We have shown that intravenous (i.v.) administration of anti-methotrexate (MTX) antibodies (AMAb) reduces the systemic exposure of intraperitoneal (i.p.) MTX therapy, and we have proposed that AMAb effects on MTX systemic exposure would allow a reduction in MTX-induced systemic toxicity (i.e., produ

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