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Pharmacodynamic Model of the Effects of Morphine and Morphine-6-Glucuronide During Patient-Controlled Analgesia

✍ Scribed by Kramer, T.H.; d'Amours, R.H.; Buettner, C.


Book ID
110019711
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
161 KB
Volume
59
Category
Article
ISSN
0009-9236

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✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,