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Pharmacodynamic (Hemodynamic) and pharmacokinetic comparisons of S-amlodipine gentisate and racemate amlodipine besylate in healthy Korean male volunteers: Two double-blind, randomized, two-period, two-treatment, two-sequence, double-dummy, single-dose crossover studies

✍ Scribed by Bo-Hyung Kim; Jung-Ryul Kim; Min-Gul Kim; Kyu-Pyo Kim; Bong-Yong Lee; In-Jin Jang; Sang-Goo Shin; Kyung-Sang Yu


Book ID
113544148
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
313 KB
Volume
32
Category
Article
ISSN
0149-2918

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✍ Idrian GarcΓ­a-GarcΓ­a; Carlos A GonzΓ‘lez-Delgado; Carmen M Valenzuela-Silva; Alin πŸ“‚ Article πŸ“… 2010 πŸ› BioMed Central 🌐 English βš– 297 KB

## Background Interferon (IFN) alpha conjugation to polyethylene glycol (PEG) results in a better pharmacokinetic profile and efficacy. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety properties of a new, locally developed, 40-kDa PEG-IFN alpha-2b preparation wi