Pharmaceutical statistics: Practical and clinical applications. Second edition. By Sanford Bolton. Marcel Dekker: New York. 1990. xvii + 646 pp. 16 × 23 cm. ISBN 0-8247-8267-4, $ 99.75

✍ Scribed by Carl M. Metzler

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 122 KB
• Volume: 80
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600800624

✦ Synopsis

Microemulsion rnin 30 min 60 min 1(5) 97.2 2 5.83 50.4 2 2.91' 73.6 2 4.95' 72.2 2 5.26 46.6 2 5.04' 47.8 ? 4.82' 14(5) 77.6 2 9.55 46.6 ? 5.03' 50.5 2 5.07' 28(5) 62.0 5 3.94 102.0 ? 8.7' 146.8 2 12.34' 126.8 2 9.81 73.6 2 13.71' 120.2 2 27.55 3(5) 7(5) a Results are expressed as mean ? SEM; number of observations shown in parentheses: insulin (0.6 Wkg) in microemulsion was prepared and stored at 4 "C until used; mice were fasted for 18 h. ' p < 0.05 versus fasting (0 time) plasma glucose values.

related loss of potency of insulin in the microemulsion formulation used. Therefore, insulin in a microemulsion formulation should be used shortly after the preparation and not after prolonged storage, even at 4 "C. These results cannot be extrapolated for other animals, other formulations, or other routes of administration. Therefore, further studies are warranted to examine the potency of insulin in the micro-

BOOK REVIEWS

emulsion after prolonged storage and in other animals, and to examine other routes of administration.