โ Scribed by Sanford Bolton, Charles Bon
No coin nor oath required. For personal study only.
The fourth edition of this text includes a disk with special programs to aid in problem analysis. The text presents fresh material on concept conformity and release targets and describes linear regression and correlation, the analysis of variance and crossover designs.
PREFACE......Page 11
CONTENTS......Page 13
BASIC DEFINITIONS AND CONCEPTS......Page 22
DATA GRAPHICS......Page 52
INTRODUCTION TO PROBABILITY: THE BINOMIAL AND NORMAL PROBABILITY DISTRIBUTIONS......Page 70
CHOOSING SAMPLES......Page 103
STATISTICAL INFERENCE: ESTIMATION AND HYPOTHESIS TESTING......Page 117
SAMPLE SIZE AND POWER......Page 172
LINEAR REGRESSION AND CORRELATION......Page 194
ANALYSIS OF VARIANCE......Page 236
FACTORIAL DESIGNS......Page 286
TRANSFORMATIONS AND OUTLIERS......Page 310
EXPERIMENTAL DESIGN IN CLINICAL TRIALS......Page 332
QUALITY CONTROL......Page 394
VALIDATION......Page 437
NONPARAMETRIC METHODS......Page 485
OPTIMIZATION TECHNIQUES AND SCREENING DESIGNS*......Page 527
GLOSSARY......Page 561
Appendix I SOME PROPERTIES OF THE VARIANCE......Page 563
Appendix II COMPARISON OF SLOPES AND TESTING OF LINEARITY: DETERMINATION OF RELATIVE POTENCY......Page 566
Appendix III MULTIPLE REGRESSION......Page 572
Appendix IV TABLES......Page 578
Appendix V OUTLIER TESTS AND CHEMICAL ASSAYS......Page 599
Appendix VI SHOULD A SINGLE UNEXPLAINED FAILING ASSAY BE REASON TO REJECT A BATCH?......Page 606
Appendix VII WHEN IS IT APPROPRIATE TO AVERAGE AND ITS RELATIONSHIP TO THE BARR DECISION......Page 615
Appendix VIII EXCEL WORKBOOKS AND SAS PROGRAMS......Page 620
Appendix IX AN ALTERNATIVE SOLUTION TO THE DISTRIBUTION OF THE INDIVIDUAL BIOEQUIVALENCE METRIC......Page 732
ANSWERS TO EXERCISES......Page 743
INDEX......Page 764
๐ SIMILAR VOLUMES
The fourth edition of this text includes a disk with special programs to aid in problem analysis. The text presents fresh material on concept conformity and release targets and describes linear regression and correlation, the analysis of variance and crossover designs.
The coverage progresses from basic definitions and concepts, data graphics, and probability through ANOVA, factorial designs, and optimization techniques. The discussion and examples have been expanded to include GMPs, validation, and quality control, as well as procedures and analyses in bioequival
Through the use of practical examples and solutions, this timely Fifth Edition has been updated and expanded to provide the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly clinical trials and bioequivalenc
Through the use of practical examples and solutions, this timely Fifth Edition has been updated and expanded to provide the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly clinical trials and bioequivalenc
Univ. of Iowa, Iowa City. Revised and expanded test presents a comprehensive and integrated approach to drug dosage formulation, design, and evaluation. Contains the latest innovation in drug production, delivery, and targeting.