Pharmaceutical heterogeneous systems IV: A kinetic approach to the stability screening of solid dosage forms containing aspirin
✍ Scribed by H. V. Maulding; M. A. Zoglio; F. E. Pigois; M. Wagner
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 437 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
icillin G (Na) in methanolic HCI. In this case, in addition to the penicillin G zone, two other spots were detected. One of these (Rf 1.12 in System A ) corresponded to the methyl a-D-penicilloate spot obtained with solutions in absolute methanol, while the substance giving the other unidentified spot (Rl's: A , 0.49; B, 0.28) is presumably benzylpenillic acid (11) which is the normal rearrangement product of benzylpenicillin in acid solution. Spots corresponding in Rf values to I1 have been detected in deteriorated procaine penicillin G solutions in water.
The TLC procedures described should be applicable to the detection of procaine and its degradation products in the presence of other drugs which are formulated with procaine, e.g., epinephrine, ephedrine, morphine, scopolamine, paromomycin, dihydrostreptomycin. Since these latter compounds and penicillin G do not give color reactions with the Bratton-Marshall reagent (12), it should be possible to use this reaction as the basis for the assay of procaine in the presence of these corrpounds. Although the Bratton-Marshall reagent has been used for the assay of procaine penicillin G (13), the trethod appears to have been largely neglected by other workers. The usefulness of this reagent for the assay of procaine is presently being assessed in these laboratories.