Pharmaceutical applications of solid dispersion systems: Dissolution of griseofulvin–succinic acid eutectic mixture

✍ Scribed by Win L. Chiou; Sarfaraz Niazi

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 349 KB
• Volume: 65
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600650820

✦ Synopsis

The dissolution profile of the griseofulvin-succinic acid eutectic mixture system was evaluated using the powder and constant-surface area tablet methods. Factors contributing to the enhancement of griseofulvin dissolution from the dispersion in succinic acid are discussed. Contrary to the original proposal of Sekiguchi and coworkers, dissolution rates of griseofulvin from solid dispersions were found to be markedly affected by the particle size of solid dispersions.

Keyphrases Dispersion systems, solid-evaluation of dissolution profile of griseofulvin-succinic acid eutectic mixture system, effect of particle size 0 Dissolution-griseofulvin from dispersion in succinic acid, profile evaluated, effect of particle size 0 Griseofulvin-dissolution from dispersion in succinic acid, profile evaluated, effect of particle size 0 Antifungal agents-griseofulvin, dissolution from dispersion in succinic acid, profile evaluated