Pharmaceutical applications of peptidomimetics

✍ Scribed by Maher Qabar; Jan Urban; Charles Sia; Michel Klein; Michael Kahn

• Book ID: 104634220
• Publisher: Springer Netherlands
• Year: 1996
• Tongue: English
• Weight: 402 KB
• Volume: 3
• Category: Article
• ISSN: 1573-3149
• DOI: 10.1007/bf00131082

✦ Synopsis

Nature has used a 'library approach' to constructing ligands for specific receptors and enzymes by combining a limited functional diversity of 20 amino acid side chains with a small array of secondary structure motifs -reverse turns, co-helices and [3-strands. The dissection of multidomain proteins into small synthetic conformationally restricted components is an important step in the design of low-molecular-weight nonpeptides that mimic the activity of the native protein. Mimetics of critical functional domains might possess beneficial properties with regard to specificity and therapeutic potential compared to the intact proteinaceous species. Combinatorial secondarystructure-templated libraries provide a powerful engine for the development of novel vaccines and pharmaceuticals.