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Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres

✍ Scribed by Li Feng; Xian Rong Qi; Xing Jun Zhou; Yoshie Maitani; Shi Cong Wang; Yang Jiang; Tsuneji Nagai

Book ID
113691176
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
289 KB
Volume
112
Category
Article
ISSN
0168-3659

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A single-shot Hepatitis B vaccine formulation using poly(d,l)-lactide-co-glycolide acid (PLGA) microspheres as a delivery system was examined using a variety of biophysical and biochemical techniques as well as immunological evaluation in C3H mice. PLGA microsphere encapsulation of the Hepatitis B s