Phagocytosis of Leishmania donovani amastigotes is Rac1 dependent and occurs in the absence of NADPH oxidase activation

NADPH oxidase-derived superoxide Anion-i

NADPH oxidase-derived superoxide Anion-induced apoptosis is mediated via the JNK-dependent activation of NF-κB in cardiomyocytes exposed to high glucose

✍ Kun-Hsi Tsai; Wei-Jan Wang; Cheng-Wen Lin; Peiying Pai; Tung-Yuan Lai; Chen-Yen 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 982 KB

## Abstract Hyperglycemia‐induced generation of reactive oxygen species (ROS) can lead to cardiomyocyte apoptosis and cardiac dysfunction. However, the mechanism by which high glucose causes cardiomyocyte apoptosis is not clear. In this study, we investigated the signaling pathways involved in NADP