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Phagocytosis by rabbit polymorphonuclear leukocytes: The effect of albumin and polyamino acids on latex uptake

✍ Scribed by Frans A. Deierkauf; Harm Beukers; Martha Deierkauf; Jelle C. Riemersma

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
504 KB
Volume
92
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Albumin in low concentrations (0.001–0.01 weight percent) was found to be an effective inhibitor of phagocytosis of polystyrene latex beads by rabbit polymorphonuclear leukocytes. Polyglutamic acid proved to be an inhibitor of latex uptake at even lower concentrations. Polylysine stimulates phagocytosis, maximal stimulation occurring at 0.002% polylysine. These findings are discussed with reference to the surface properties of latex particles and leukocytes, and particularly with reference to electrostatic interactions in phagocytosis.

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