Ionophore and Anthelmintic Activity of P
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Geßner, Guido; Meder, Sabine; Rink, Thomas; Boheim, Günther; Harder, Achim; Jesc
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Article
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1996
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John Wiley and Sons
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English
⚖ 841 KB
PF 1022A, a 24-membered cyclooctadepsipeptide and a potent anthelmintic drug, is active against nematodes but not against arthropods. Muscle cells of Ascaris suum generate autorhythmic spikes in electrophysiological control experiments. Exposure of the worm to PF 1022A leads to flaccid paralysis and