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Phagocytosis and comparative innate immunity: learning on the fly

✍ Scribed by Stuart, Lynda M.; Ezekowitz, R. Alan


Book ID
109955821
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
706 KB
Volume
8
Category
Article
ISSN
1474-1741

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## Abstract Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in preclinical gene therapy models and in a range of clinical trials. However, innate immune responses to adenovirus vectors limit effectiveness of Ad5 based therapies. Moreover, extensive pre‐existing Ad5 imm